I really don't know but
most of these "little USB interfaces" are plug-and-play with the standard Microsoft-supplied and Apple-supplied drivers and I
guess Linux has drivers that work just like the Microsoft & Apple drivers.
If a USB mic works most 1 or 2 channel interfaces should also work.
Quote:
I can hear audio output on my headphones plugged into my interface
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That interface has zero-latency direct-hardware monitoring so the monitoring path doesn't have to go through the computer. You just need USB power.