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However, can anyone advise if I'm likely to have issues trying to setup Reaper 4.78x64.
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Hi Ron,
I still have 4.78 x64 installed here on Windows 10 64-bit (besides version 5.x) and I can't remember that I had any issues with using version 4 on Windows 10 (before switching completely to 5).
In addition, I just started 4.78 up again to do a quick test playback of a demo project and it works fine. As a side note: no Windows 7 compatibility mode necessary here for running 4.78 on Win 10.
I'd say it's more likely that there might perhaps be Windows 10 compatibility issues with certain 3rd-party plugins or hardware (audio interface, USB-MIDI controller/keyboard, etc.). So, if you haven't already, I'd recommend to double-check Windows 10 compatibility for those things in advance, as well.
EDIT: If you're using SWS Extensions, 2.7.0 seems to be the latest SWS version working with Reaper 4.78 - available on the SWS Extensions page under 'Additional downloads'.