Just wanted to add my story.
A month a go I installed some Computer Music plug-ins on a fairly new computer and Reaper wouldn't recognize. Then tried with an older computer which had an older version of Reaper on it and Reaper loaded them perfectly.
However, I was running PC's with XP. But as an important side note, it wasn't just Reaper that didn't see the plugs on the newer computer as I had Samplitude installed with same issue. I never bothered to isolate the problem.
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