Some plugins have more latency than others, which are you using?
And sound cards will always have a little bit too. The direct monitoring is for the card only (ins and outs), here we're talking about ASIO driver (I assume you are using) and then there will be some latency, but normally 10-20 ms is anyway acceptable and will feel as if there were no latency, especially for effects.
So in summary:
1. Use only effects that don't have high latency. The different plugins latency values can be seen in Reaper's performance meter (ctrl-alt-P) under the PDC column there (Plugin Latency Compensation).
and
2. set your sound card's ASIO to as low latency as possible (without the sound starting to crackle etc)
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