Probably something simpler, yes. It just triggered that memory for me. If you had already tried everything troubleshooting, then maybe go out into the weeds like that.
What have you tried?
For example, did the project continue to be distorted after saving it, closing Reaper, and reopening it? How about opening an older version? (That would assume you hit 'save as' here and there and update the project name and keep multiple revisions.) There's your tip of the day.
By total distortion you mean garbled constant blasted out as opposed to clicks and pops? Hard drive read troubles usually give you clicks and pops. It's the sound of dropouts. Connection issues with the audio interface often result in distorted sound.
I usually check the interface connection first.
If some other app messes with the audio in the background, sending a new request from Reaper would fix it. So...
Open Reaper Preferences/Audio/Device. Select your interface from the device menu (even though it already appears selected). The 'apply' button will ungrey. Click it.
Try that if there's a next time.
It could be something wildly left field different of course. A laptop with less than good cooling might overheat after an hour and start throttling CPU.
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