The bridges can run both 32 and 64 bit plugins on both 32 and 64 bit Reaper. The mode where both the main Reaper app and the bit bridge run at the same bit architecture may be useful for dealing with buggy plugins.
You shouldn't use the bit bridging modes unless really needed, so "only native" is the recommended way to go.
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I am no longer part of the REAPER community. Please don't contact me with any REAPER-related issues.
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