I'm having trouble following your description of the problem.
Quote:
Originally Posted by Triode
If I copy the item to a new track and render the item as audio the new file has the same audible artifacts. - It sounds badly bit reduced and full of clipping sounds and kind of out of tune.
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Is the rendered file audio only, or still a video item? This sounds to me like some discrepancy between your project samplerate and the video's audio samplerate and/or the Playback Resample Mode in Project Settings can affect the resampling quality of actions like Gluing audio. So, that may be the source of your problem.
Quote:
Originally Posted by Triode
If I open the video file outside of reaper in an instance of VLC it plays perfectly.
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Which file are you referring to here? The original, the copied render, or the render of the project with/without the copied render?