Apparently Prologix is tailored for the dual monitor use or working only with arrange or mixer at any given time, unless you have a big/high res monitor. But unlike some big themes, you can resize the mixer somewhat. That might not be enough though and the features available in MCP too limited because of the resized panels hiding some controls.
Only setup I've made to work with all the themes, not just the big ones, is that I have prepared several different screensets so I can switch between them fast. That way I can avoid some extra clicking, moving and resizing.
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