I'd like to add a tip for getting a good guitar tone with modeled amps and cab-IR's if I may
* Before you start EQ-ing, try other cab-IR's to get the sound you want.
I use ReaVerb for IR-loading because it allows for mousewheel-scrolling through different IR files in a folder. I get my full mix up and scroll through them until I find a color that matches the existing palette sorta-speak. Don't rely on 'that IR you used last time'. Picking a brighter sounding cab gives you a much more natural high-boost then shelving at 5K in a parametric EQ.