The "Audio/MIDI Setup" menu is not needed in the plug-in. It is used in a standalone program to connect the program to the hardware. You'll see the equivalent in Reaper's Preferences.
The MIDI into a plug-in and the audio out from the plug-in are connected to the host program (Reaper) in accordance with the plug-in specification.
@ivansc, can you attach a small SD3 project for nroozebo to try?
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DarkStar ... interesting, if true. . . . Inspired by ...
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