I found the solution...
I was using Aggregate device on my mac to be able to use both my Audient iD14 and AXE for outputs. In macs utility Audio Midi setup there was a checkbox 'drift correction'. I unchecked it and now the noises are gone.
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Reaper 6.13/64 - Audient iD14 Interface-Mac Mini 2.3Ghz i7, 16GB RAM 256GB SSD (OS,apps) & 1TB HDD (data), OS X 10.14.6 - Macbook Pro 2.2Ghz i7, 4 GB RAM, 256GB SSD (OS,apps) OS X 10.13.6 - Presonus Faderport
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