With Reaper 3.05, Macbook, 10.4.11, I know of these problems with plugins:
Pod Farm AU - Very slow to load, it doesnt always respond to mouse clicks or mouse wheel adjustments, and then when its removed it leaves a huge white space on Reaper's GUI where it used to be.
Pod Farm VST - Doesnt load.
Audio Damage Reverence (now ADverb) - AU silences output, VST works fine.
Mason Soft Dammit - Wont load.
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