From Someone who sells all kinds of interfaces I would say be cautious with the alesis I have had a ton of customers with compatability issues. Right now I think the best option on the market is M-Audio Profire 2626. This piece is light years ahead of the old M-Audio stuff. The D/A converters are the same chipset that RME uses in their pieces. I have two of these and they have been trouble free with Reaper.
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