The manual seems to imply yes...
https://www.rme-audio.de/download/dface_usb_e.pdf
Quote:
21.6 Recording a Submix - Loopback
TotalMix includes an internal loopback function, from the Hardware Outputs to the recording
software. Instead of the signal at the hardware input, the signal at the hardware output is sent to
the record software. This way, submixes can be recorded without an external loopback cable.
Also the playback from a software can be recorded by another software.
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