If you want to make an experiment, I can run the same heavy loaded Reaper project for with my BT 4.0 dongle (and wireless mouse) connected and then run it again with a wired mouse.
Anyway, here's my system's report, while still having Firefox running, also running Reaper with a dozen of heavy synths, audio tracks and a couple dozens of fx (48 FX total). And, of cause, with both BT dongle and mouse connected.
https://i.imgur.com/6LdVd3w.png