I have a similar problem on my laptop win 64, latest Reaper, specifically with Native Instruments vsts. Problem started like one month ago, doubt it's a hardware question. I have a Presonus interface and a Komplete midi controller.
NI's stuff simply disappears (Komplete Kontrol, Kontakt 64 bit, Maschine 2, Raum, etc... I manually removed the 32 vst folder from Native's folder, just to force Reaper to look for the 64 bit versions during the clear cache and rescan procedure (done it many times), since for some reason Reaper could only find Kontakt player 32.
I have Kontakt play installed (the free version). Atm, I suspect it has something to do with later Reaper updates.
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