Interesting. I am way past you on os updates & the ONLY issue I have is that every time Windoze decides to set my audio outputs to thwe wrong pair of speaker outs on my RME interface. A one click fix once you are used to it.
I also have B4II and it is still working fine for me in 64bit Win10 Pro. Only "issue" is that it shows the splash screen and asks if I want to run im demo mode every time I instantiate it. Just click the screen away and everything works as it should. Might bwe worth checking what is showing in Native Access.
If you get really stuck & no longer have your original CD I might be able to help.
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