Thanks, I've now tested with your ini, and it's still fine here.
Can you test without any MIDI devices open and without any control surfaces configured? Also, test with using WaveOut and a 1024 sample blocksize (rather than ASIO)?
Additionally: try going to preferences/buffering, unchecking auto-detect the number of threads, and manually enter something like 4. (what was it detecting? 16?).
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