I very happily use Reaper as a "VST Player" for playing piano sounds and solo Flute with two masterkeyboards and a TEC BBC (for rehearsal and on stage).
I use an NI Audio 6 interface for Midi in and Audio out.
I once tried to run an electric Guitar directly in the Audio6 and then through NI GuitarRig and mix in the Audio with Reaper.
Worked nicely.
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