First: do you plan to run native Linux software only (such as I do) or do you want to use Windows plugins (etc.)
Second: what software do you plan to run (Linux software).
Third: do you mind changing the configuration of your distro when necessary, or are you averse to that kind of thing.
A distro that's more audio-specific could be a good choice if you want to try to run "everything possible" since it'll have a low latency kernel by default, JACK and WINE etc. installed already, and hopefully configured well. However if you're only using native Linux stuff you can use just about any distro (then it's just a matter of whether the software you want to run is available in the repo for that distro, or if you have to add another software source to your package manager).
And you might have to swap kernels but that's easy to do too.
Here's a post I made explaining what I did with my distro install.
https://forum.cockos.com/showpost.ph...4&postcount=13
I have no experience installing RME products in Linux, so you'll have to search for that I guess (if no one else with that experience posts replies).