Not sure about the 1820M but back in the day Reaper worked very well with my EMU-1212M. I am far removed from that soundcard these days but you don't need to use patchmix at all with Reaper unless you're looking for customized assignments.
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Registered Reaper User: Win 7 Pro x64; Sonar X3e Pro; Reaper 4.62; AMD FX4100 3.8GHz; DDR3 1600 24GB Ram; Focusrite Scarlett 18i20; 3 x 1TB and 1 x 640 GB HDD;Mackie HR 624; KRK RP5 G2 Rokit Monitors
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