Are you using a "proper" Audio/MIDI interface or the built-in soundcard in your computer?
If you have an interface, are you using its ASIO driver within Reaper?
If you are using an ASIO driver, what ASIO buffer size are you using?
Say for arguments sake you have the ASIO buffer set at 64, try raising it to 128 ^ see if that helps.
Moving on, another thing worth trying is to download and run resplendence.com`s latency checker which will tell you if your computer setup has any issues affecting latency, which is generally the root cause of snap crackle `n pop.
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Ici on parles Franglais
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