.VST & .COMPONENT (now called AU but still with the original extension) are the native supported formats for OSX.
.DLL & .VST (I think) are the native supported formats for Windows.
There are wrappers available to run .DLL in OSX. Haven't tried any of them.
You can of course run Windows apps natively in OSX (with Wine installed). But to run a windows plugin, you would need a wrapper or you would have to launch the Windows version of Reaper and run it that way.
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