It's never great to run audio interfaces from a hub, especially a USB2 interface on a USB3 hub. I've also run into issues with a 4 port midi interface in that situation. I don't know what the problem is, but I suspect the USB2 drivers have code incompatible with the USB3 spec.
So, I use my USB3 hub only for devices it works well with: Wireless mouse & keyboard, a couple external hard drives, a wifi stick, printer/scanner, etc. But I only plug audio & midi interfaces directly into USB2 ports on the PC, never through the hub.
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