Problem solved!
The problem is "app nap".
You must disable app nap for reaper application and plugins host application.
From context menu (right click) of Reaper icon (eg. reaper64.app) choose "prevent app nap". Then from context menu choose "Show Package Contents" and go to Contents > Plugins and disable "app nap" for reaper_host_i386.app and reaper_host_x86_64.app as you done it with reaper.
Enjoy Reaper with no lags!
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