manning1,
an accessible GUI dev environment would be Flash or their new FLEX framework. I believe there's a way of hooking up ActionScript i.e. Flash scripting to C, C++, so it should not be too hard to setup the glue so that pretty Flash screen values and events are hooked to the respective Reaper API i.e. Flash can be the pretty interface that simply captures and passes values to Reaper and triggers actions in Reaper.
If you have not played with Flash, its got a wizard and painter i.e. quite friendly, its not meant for the hard core developer per se.
Just a thought,
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