I am just getting started running Reaper under Wine in Linux Mint 18 KDE
It seems to work well, I have had little trouble installing plugins, themes and so far, the latency is quite low, acceptable. Running it all on an older i7 laptop (4 cores). So far I have not attached a real audio interface, its all MIDI at this point.
Its a novelty for me, as I have both Windows and Mac machines to run various DAWs on, but if this really could fly in times to come, I would willingly ditch these bloated WinMac OSes for a Linux variant. Ubuntu Studio is a good distro to get started with as mentioned above.
Some good reading here....
https://linuxmusicians.com/
Cheers